Kieślowski's "Trois Couleurs" Trilogy

Eulerian Trilogy

Three Eulerian models are implemented on a network graph model of air traffic flow. The underlying network is constructed using one year of ASDI/ETMS data. The three models are applied to high altitude traffic for a full Air Route Traffic Control Center of the National Airspace System and surrounding airspace. Simulations are carried out for a full day of data, to assess the predictive capabili...

Resource Discovery in Trilogy

Trilogy is a collaborative project whose key aim is the development of an integrated virtual laboratory to support research training within each institution and collaborative projects between the partners. In this paper, the architecture and underpinning platform of the system is described with particular emphasis being placed on the structure and the integration of the distributed database. A ...

Synaptic Ménage à Trois

Regulation of neurotransmitter receptor localization is critical for synaptic function and plasticity. In this issue of Neuron, Matsuda and colleagues (Matsuda et al., 2016) uncover a transsynaptic complex consisting of neurexin-3, C1q-like proteins, and kainate receptors that drives glutamate receptor clustering at hippocampal synapses.

Ménage à trois

Ménage à trois

Glioblastoma is an aggressive primary brain cancer. Given our interest in novel immunotherapies, we have recently shown that inhibiting CTLA-4, PD-L1 and IDO results in a dramatic survival advantage in mice with brain tumors. Our preclinical study supports the rapid translation of this approach into phase I clinical trial.